The Rising Price of Naloxone - Risks to Efforts to Stem Overdose Deaths.

The Food and Drug Administration (FDA) first approved naloxone in 1971 as an injection (Narcan) for reversing opioid intoxication or overdose. Although the brand-name version has been discontinued, generic versions of naloxone have been available since 1985, and today injections are available in two doses (0.4 mg per milliliter and 1 mg per milliliter; see table below. Recent and Current Prices for Naloxone.). In 2014, the FDA fast-tracked approval of the first auto-injector formulation (Evzio), a fixeddose single injection designed to allow people without medical training to reverse opioid overdose. In 2015, the agency fast-tracked approval of the first nasal-spray formulation (also marketed as Narcan); previously, naloxone injections (larger vials of a 1-mg-per-milliliter dose) had routinely been used offlabel with an atomizer for nasal delivery.